Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | TET3 | O43151 | 2/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL27687150 | 0.83 | SMN1; SMN2 (0.75) | SMN1; SMN2OR51E2TET2KDM4AKDM4C | |
| Malic Acid SCHEMBL28874241 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2OR51E2TET2KDM4AKDM4C | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL28436479 | 0.81 | GPR84 (0.36) | SMN1; SMN2SLC22A6GPR84FFAR1PTPN1 | |
| Cadaverine Tartrate SCHEMBL28437587 | 0.79 | TSHR (0.46) | OR51E2GPR84FFAR1PTPN1TDP1 | |
| Glycolic Acid SCHEMBL11515132 | 0.79 | CAMK2A (0.42) | OR51E2GPR84FFAR1PTPN1CAMK2A | |
| Bicarbonate SCHEMBL1357296 | 0.79 | CAMK2A (0.39) | OR51E2GPR84FFAR1PTPN1TDP1 | |
| Malic Acid SCHEMBL27748793 | 0.79 | SMN1; SMN2 (0.83) | SMN1; SMN2OR51E2TET2KDM4AKDM4C | |
| Malic Acid SCHEMBL28317492 | 0.79 | SMN1; SMN2 (0.83) | SMN1; SMN2OR51E2TET2KDM4AKDM4C | |
| Malic Acid SCHEMBL193758 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2OR51E2TET2KDM4AKDM4C | |
| Lactic Acid SCHEMBL3674424 | 0.78 | TP53 (0.48) | OR51E2GPR84FFAR1PTPN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111683644-B | Composition for forming coating film | 花王株式会社 | 2023-05-09 | — | — | CN | disclosed |
| CN-105793337-B | The method for preparing the polyester form particle of expansion | 巴斯夫欧洲公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-105814126-A | Process for the production of expanded polyester foam beads | 巴斯夫欧洲公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105793040-A | Polymer mixture for barrier film | 巴斯夫欧洲公司 | 2016-07-20 | — | — | CN | disclosed |
| CN-105793337-A | Method for producing expanded polyester foam particles | 巴斯夫欧洲公司 | 2016-07-20 | — | — | CN | disclosed |