Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.63 |
| ▸ | TACR1 | P25103 | 14/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16956459 | 0.88 | IDO1 (0.50) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL25112325 | 0.86 | IDO1 (0.48) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL4977101 | 0.86 | IDO1 (0.53) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL25112281 | 0.83 | IDO1 (0.50) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL20905127 | 0.82 | IDO1 (0.44) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL20698868 | 0.82 | IDO1 (0.44) | IDO1TACR1CACNA1H | |
| SCHEMBL4975333 | 0.80 | IDO1 (0.43) | IDO1ALDH1A1 | |
| SCHEMBL171782 | 0.79 | IDO1 (0.68) | IDO1SLC6A4 | |
| SCHEMBL791992 | 0.79 | GABRA1 (0.48) | IDO1TACR1 | |
| SCHEMBL5779082 | 0.78 | IDO1 (0.48) | IDO1TACR1CACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023121939-A1 | SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-06-29 | — | — | WO | disclosed |
| US-10807951-B2 | mTORC1 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-10-20 | — | — | US | disclosed |
| WO-2019075386-A1 | MTORC1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-04-18 | — | — | WO | disclosed |
| US-20190112268-A1 | mTORC1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-18 | — | — | US | disclosed |
| EP-2704568-B1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | MERCK SHARP & DOHME (US) | 2018-01-24 | — | — | EP | disclosed |
| WO-2017190038-A1 | ANALOGS OF YOHIMBINE AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-11-02 | — | — | WO | disclosed |
| US-20170204086-A1 | ALPHA-HELIX ANALOG HAVING TRIAZINE-PIPERAZINE BACKBONE AND METHOD FOR PREPARING SAME | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2017-07-20 | — | — | US | disclosed |
| US-9272987-B2 | Diazeniumdiolate cyclohexyl derivatives | MERCK SHARP & DOHME CORP. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20140088048-A1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2014-03-27 | — | — | US | disclosed |
| US-8133994-B2 | Preparation of aprepitant | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-20110094321-A1 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-04-28 | — | — | US | disclosed |
| US-7872022-B2 | Serotonin transporter (SERT) inhibitors for the treatment of depression and anxiety | HOFFMANN-LA ROCHE INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20080009506-A1 | Imidazole Compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-01-10 | — | — | US | disclosed |
| WO-2007113153-A1 | PIPERIDINE DERIVATIVES USEFUL AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-11 | — | — | WO | disclosed |
| EP-1442019-B1 | AMIDE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3-BETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-10 | — | — | EP | disclosed |
| US-20070232652-A1 | Serotonin transporter (sert) inhibitors for the treatment of depression and anxiety | HOFFMAN-LA ROCHE INC. | 2007-10-04 | — | — | US | disclosed |
| EP-1451153-B1 | NK1 ANTAGONISTS | SCHERING CORP (US) | 2007-09-26 | — | — | EP | disclosed |
| US-7183288-B2 | Amide derivatives as glycogen synthase kinase 3-β inhibitors | FREYNE EDDY JEAN EDGARD | 2007-02-27 | — | — | US | disclosed |
| US-7183288-B2 | Amide derivatives as glycogen synthase kinase 3-β inhibitors | FREYNE EDDY JEAN EDGARD | 2007-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204086-A1 | ALPHA-HELIX ANALOG HAVING TRIAZINE-PIPERAZINE BACKBONE AND METHOD FOR PREPARING SAME | HSPH1, HBZ, PITHD1 | IDO1 3581/4885TACR1 4286/4885CACNA1F 4657/4885 |
| US-20070232652-A1 | Serotonin transporter (sert) inhibitors for the treatment of depression and anxiety | SLC6A4, SLC6A1, SLC1A2 | IDO1 619/4885TACR1 71/4885CACNA1F 1174/4885 |
| US-20110094321-A1 | PREPARATION OF APREPITANT | KIT, CPA3, CMA1 | IDO1 1622/4885TACR1 5/4885CACNA1F 2135/4885 |
| US-20080009506-A1 | Imidazole Compound | KCNH2, KCNJ2, KCNH3 | IDO1 350/4885TACR1 470/4885CACNA1F 40/4885 |
| US-20190112268-A1 | mTORC1 MODULATORS | MTOR, RPTOR, RICTOR | IDO1 3976/4885TACR1 4699/4885CACNA1F 3703/4885 |
| US-20140088048-A1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | CBR3, OR10J3, CBR1 | IDO1 781/4885TACR1 281/4885CACNA1F 1227/4885 |
| US-10807951-B2 | mTORC1 modulators | MTOR, RPTOR, RICTOR | IDO1 3976/4885TACR1 4699/4885CACNA1F 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.