Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28217086 | 0.80 | MAPT (0.43) | IDO1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9322402 | 0.80 | GPR174 (0.49) | GPR174IDO1MAOAMAOBALDH1A1 | |
| SCHEMBL28059585 | 0.76 | MAPT (0.50) | IDO1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL21933079 | 0.75 | MAPT (0.52) | ALDH1A1MAPTMEN1KMT2APTPN7 | |
| SCHEMBL28187507 | 0.74 | HTT (0.38) | IDO1ALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL941357 | 0.72 | NAPRT (0.47) | GPR174ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3937557 | 0.72 | ALDH1A1 (0.39) | IDO1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11313866 | 0.72 | IDO1 (0.42) | IDO1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL27631576 | 0.71 | HTT (0.46) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL941518 | 0.69 | MAPT (0.43) | ALDH1A1MAPTMEN1KMT2APTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-105492437-A | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | KARYOPHARM THERAPEUTICS INC | 2016-04-13 | — | — | CN | disclosed |