Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | RHOC | P08134 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28217086 | 0.78 | MAPT (0.43) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28059659 | 0.76 | GPR174 (0.35) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL11409430 | 0.74 | L3MBTL1 (0.51) | MAPTMEN1KMT2ANPSR1GAA | |
| SCHEMBL14995940 | 0.74 | L3MBTL1 (0.65) | MAPTMEN1KMT2ANPSR1GAA | |
| SCHEMBL29876277 | 0.73 | L3MBTL1 (0.54) | MAPTMEN1KMT2ANPSR1GAA | |
| SCHEMBL31590848 | 0.73 | L3MBTL1 (0.54) | MAPTMEN1KMT2ANPSR1GAA | |
| SCHEMBL27373525 | 0.72 | ALDH1A1 (0.44) | MAPTMEN1KMT2ANPSR1GAA | |
| SCHEMBL11406613 | 0.72 | L3MBTL1 (0.53) | MAPTMEN1KMT2ANPSR1GAA | |
| SCHEMBL13434288 | 0.72 | L3MBTL1 (0.50) | MAPTMEN1KMT2ANPSR1GAA | |
| SCHEMBL17681586 | 0.71 | MAPT (0.51) | MAPTMEN1KMT2ANPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-105492437-A | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | KARYOPHARM THERAPEUTICS INC | 2016-04-13 | — | — | CN | disclosed |