Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17275723 | 0.71 | ALDH1A1 (0.50) | GAAALDH1A1LMNAMCL1PAX8 | |
| SCHEMBL8911633 | 0.71 | LMNA (0.41) | GAAALDH1A1LMNAMCL1PAX8 | |
| SCHEMBL15907068 | 0.69 | ALDH1A1 (0.39) | GAAALDH1A1LMNAMCL1PAX8 | |
| SCHEMBL11882604 | 0.66 | TTR (0.52) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL2393621 | 0.65 | LMNA (0.57) | GAAALDH1A1LMNAMCL1PAX8 | |
| SCHEMBL29565250 | 0.64 | ALDH1A1 (0.47) | GAAALDH1A1LMNAMCL1PAX8 | |
| SCHEMBL31395894 | 0.62 | ALDH1A1 (0.39) | GAAALDH1A1LMNAMCL1PAX8 | |
| SCHEMBL2393560 | 0.62 | ALDH1A1 (0.39) | GAAALDH1A1LMNAMCL1PAX8 | |
| SCHEMBL20618813 | 0.60 | ALDH1A1 (0.47) | GAAALDH1A1LMNAMCL1PAX8 | |
| SCHEMBL21726115 | 0.60 | MAPT (0.40) | GAAALDH1A1LMNAMCL1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105395550-B | Contain 2 with substituted oxy, the glucocorticoid receptor agonist of 2,4- trimethyl -6- phenyl -1,2- dihydroquindine derivates | 步制药股份有限公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-105395550-A | GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO LTD | 2016-03-16 | — | — | CN | disclosed |