Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL28238648 | 0.96 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL7028937 | 0.93 | MAPT (0.43) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL6942949 | 0.93 | MAPT (0.41) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL424215 | 0.89 | MAPT (0.42) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL15066242 | 0.89 | MAPT (0.44) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL1267231 | 0.89 | MAPT (0.44) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL28235393 | 0.86 | MAPT (0.40) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL8576218 | 0.86 | MAPT (0.40) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL29008262 | 0.85 | MAPT (0.43) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL8651857 | 0.85 | MAPT (0.43) | MAPTKDM4EALOX15SMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829466-B | Flame-retardant coating agent for vehicle seat and method for producing flame-retardant vehicle seat material | 日华化学株式会社 | 2018-11-23 | — | — | CN | disclosed |
| CN-108178943-A | The manufacturing method of vehicular seats anti-flammability smears and anti-flammability seat material | 日华化学株式会社 | 2018-06-19 | — | — | CN | disclosed |
| CN-105829466-A | Flame-retardant coating agent for vehicle seat and method for producing flame-retardant vehicle seat material | 日华化学株式会社 | 2016-08-03 | — | — | CN | disclosed |