Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL7028937 | 0.96 | MAPT (0.43) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL81804 | 0.92 | MAPT (0.44) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL3986143 | 0.92 | MAPT (0.44) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL30539261 | 0.92 | MAPT (0.44) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL28403643 | 0.92 | MAPT (0.44) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL28060694 | 0.89 | MAPT (0.40) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL8576218 | 0.89 | MAPT (0.40) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL28235393 | 0.89 | MAPT (0.40) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL8651857 | 0.88 | MAPT (0.43) | MAPTKDM4EALOX15SMN1; SMN2CA12 | |
| Trolamine SCHEMBL29008262 | 0.88 | MAPT (0.43) | MAPTKDM4EALOX15SMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120301406-A1 | SKIN CARE COMPOSITION WITH INDICATING FUNCTION AND METHOD OF USING THE SAME | TAIWAN TEXTILE RESEARCH INSTITUTE (TW) | 2012-11-29 | — | — | US | claimed |
| US-10822373-B2 | Methods for synthesizing phycocyanin using a biological substance | ZHENG CHENGHUI (US) | 2020-11-03 | — | — | US | disclosed |
| US-20200216489-A1 | METHODS FOR SYNTHESIZING PHYCOCYANIN USING A BIOLOGICAL SUBSTANCE | ZHENG CHENGHUI (US) | 2020-07-09 | — | — | US | disclosed |
| EP-2606959-B1 | USE OF AN OXYGEN ABSORBER AND METHOD FOR STORING THE SAME | MITSUBISHI GAS CHEMICAL CO (JP) | 2017-06-07 | — | — | EP | disclosed |
| EP-2360529-B1 | METHOD FOR MANUFACTURING LITHOGRAPHIC PRINTING PLATE, DEVELOPER FOR ORIGINAL LITHOGRAPHIC PRINTING PLATE, AND REPLENISHER FOR DEVELOPING ORIGINAL LITHOGRAPHIC PRINTING PLATE | FUJIFILM CORP (JP) | 2016-08-24 | — | — | EP | disclosed |
| US-20160138059-A1 | Method for Manufacturing Optically Active Fluorolactic Acid Derivative | CENTRAL GLASS COMPANY, LIMITED (JP) | 2016-05-19 | — | — | US | disclosed |
| EP-3020818-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE FLUOROLACTIC ACID DERIVATIVE | Central Glass Company, Limited (JP) | 2016-05-18 | — | — | EP | disclosed |
| US-9315383-B2 | Oxygen absorbing agent and method for storing the same | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2016-04-19 | — | — | US | disclosed |
| EP-2339401-B1 | Method of preparing lithographic printing plate | FUJIFILM CORP (JP) | 2016-02-17 | — | — | EP | disclosed |
| US-20130209350-A1 | OXYGEN ABSORBING AGENT AND METHOD FOR STORING THE SAME | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2013-08-15 | — | — | US | disclosed |
| US-20070141596-A1 | PLATE, DETERMINATION KIT, AND DETERMINATION METHOD FOR IMMUNOASSAY | PENTAX CORPORATION (JP) | 2007-06-21 | — | — | US | disclosed |
| EP-1777522-A1 | Plate, kit and method for the determination of a virus infection | PENTAX Corporation (JP) | 2007-04-25 | — | — | EP | disclosed |
| EP-1777521-A1 | Method and kit for the determination of HIV infection | PENTAX Corporation (JP) | 2007-04-25 | — | — | EP | disclosed |
| CN-1307878-C | Nimbin micro capsule suspension formulation | UNIV YUNNAN (CN) | 2007-04-04 | — | — | CN | disclosed |
| WO-2007020218-A1 | PROCESS TO REMOVE NON-BIODEGRADABLE COMPOUNDS FROM AN AQUEOUS COMPOSITION AND APPARATUS THEREFOR | AKZO NOBEL N.V. (NL) | 2007-02-22 | — | — | WO | disclosed |
| US-20060270037-A1 | COLLAGEN-COATED CARRIER AND METHOD FOR MANUFACTURING COLLAGEN-COATED CARRIER | PENTAX CORPORATION (JP) | 2006-11-30 | — | — | US | disclosed |
| EP-0566140-B1 | Method for producing dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof | UNITIKA LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| US-5306629-A | Two-stage reaction using two enzymes: adenosine-5-triphosphate sulfurylase and diadenosine tetraphosphate phosphorylase as catalysts, and adenosine-5-triphosphate, polyphosphate and a sulfate as substrates | UNITIKA LTD. (JP) | 1994-04-26 | — | — | US | disclosed |
| EP-0566140-A2 | Method for producing dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof | UNITIKA LTD. (JP) | 1993-10-20 | — | — | EP | disclosed |
| US-4367072-A | Ligands assayed by host molecules including cyclophanes, crown ethers, crypstands and podands | BOEHRINGER MANNHEIM GMBH (DE) | 1983-01-04 | — | — | US | disclosed |