Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.45 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.45 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1400657 | 0.87 | NPSR1 (0.50) | HTTPTGIRTSHRNPSR1NPC1 | |
| SCHEMBL7982484 | 0.79 | HTT (0.49) | HTTGAAKCNA5KCNN4PTGIR | |
| SCHEMBL11613500 | 0.79 | CYP1A2 (0.61) | HTTTSHRMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL10855623 | 0.77 | RECQL (0.41) | HTTGAAMAPTGFERNPSR1 | |
| SCHEMBL1648430 | 0.76 | KCNA5 (0.47) | HTTGAAKCNA5KCNN4PTGIR | |
| SCHEMBL7112425 | 0.76 | KCNA5 (0.47) | HTTGAAKCNA5KCNN4PTGIR | |
| SCHEMBL966680 | 0.75 | OPRM1 (0.51) | HTTKDM4ETSHRNPC1PKM | |
| SCHEMBL13266974 | 0.75 | RIPK1 (0.60) | PKMKMT2ASMN1; SMN2 | |
| SCHEMBL16398787 | 0.75 | GAA (0.50) | HTTGAAKCNA5KCNN4PTGIR | |
| Hydrochloric Acid SCHEMBL27470915 | 0.74 | KCNA5 (0.46) | HTTGAAKCNA5KCNN4PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102725290-B | As the condensed heterocyclic compouds of ion channel modulators | GILEAD SCIENCES, INC. (US) | 2016-03-09 | — | — | CN | claimed |
| CN-102725290-B | As the condensed heterocyclic compouds of ion channel modulators | GILEAD SCIENCES, INC. (US) | 2016-03-09 | — | — | CN | disclosed |