Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28091556 | 0.82 | FFAR4 (0.36) | ALDH1A1L3MBTL1KMT2AMAPTPOLB | |
| SCHEMBL19500067 | 0.80 | RAPGEF4 (0.47) | ALDH1A1RELAKMT2AMAPTPOLB | |
| SCHEMBL28091448 | 0.79 | FFAR4 (0.37) | NPC1RAB9AALDH1A1LMNAL3MBTL1 | |
| SCHEMBL27986391 | 0.76 | F2RL1 (0.55) | F2RL1NPC1RAB9AALDH1A1NFKB1 | |
| SCHEMBL28154615 | 0.75 | RAPGEF4 (0.67) | F2RL1ALDH1A1KMT2AMAPTTP53 | |
| SCHEMBL28802020 | 0.73 | GSK3B (0.38) | ALDH1A1KMT2AHPGDMAPTPOLB | |
| SCHEMBL28061510 | 0.73 | F2RL1 (0.51) | F2RL1NPC1RAB9AALDH1A1NFKB1 | |
| SCHEMBL7329940 | 0.73 | F2RL1 (0.85) | F2RL1NPC1RAB9AALDH1A1NFKB1 | |
| SCHEMBL27916561 | 0.70 | TUBB1 (0.39) | ALDH1A1RELAALOX5KMT2AHPGD | |
| SCHEMBL7328673 | 0.69 | F2RL1 (0.56) | F2RL1NPC1RAB9AALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906617-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-104254534-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-105906617-A | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-103038231-B | Modulators of HEC1 activity and methods thereof | Taivex Therapeutics Corp. (CN) | 2016-04-20 | — | — | CN | disclosed |