Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28061531 | 0.81 | PTGS1 (0.38) | AKR1B1PTGDR2MAPTKDM4ECYP1A2 | |
| SCHEMBL27986391 | 0.78 | F2RL1 (0.55) | F2RL1NFKB1NFKB2RELASLC5A1 | |
| SCHEMBL28061534 | 0.78 | PTGIR (0.41) | AKR1B1PTGDR2NPC1RAB9AMAPT | |
| SCHEMBL28061523 | 0.76 | ALDH1A1 (0.46) | AKR1B1PTGDR2RAB9AMAPTKDM4E | |
| SCHEMBL7329940 | 0.75 | F2RL1 (0.85) | F2RL1NFKB1NFKB2RELASLC5A1 | |
| SCHEMBL28154615 | 0.74 | RAPGEF4 (0.67) | F2RL1MAPTTP53CYP3A4SMN1; SMN2 | |
| SCHEMBL28061511 | 0.73 | F2RL1 (0.49) | F2RL1NFKB1NFKB2RELASLC5A1 | |
| SCHEMBL18723690 | 0.72 | TDP1 (0.47) | AKR1B1PTGDR2MAPTKDM4ECYP3A4 | |
| SCHEMBL28833020 | 0.72 | AKR1B1 (0.43) | AKR1B1PTGDR2MAPTALDH1A1POLB | |
| SCHEMBL7328673 | 0.71 | F2RL1 (0.56) | F2RL1AKR1B1NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906617-A | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-103038231-B | Modulators of HEC1 activity and methods thereof | Taivex Therapeutics Corp. (CN) | 2016-04-20 | — | — | CN | disclosed |