Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.43 |
| ▸ | PTGIR | P43119 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27916624 | 0.78 | PPARA (0.51) | ALDH1A1LMNAHTTRAB9AKMT2A | |
| SCHEMBL28061510 | 0.76 | F2RL1 (0.51) | ALDH1A1LMNARAB9AKMT2AMEN1 | |
| SCHEMBL28833020 | 0.76 | AKR1B1 (0.43) | ALDH1A1AKR1B1PTGDR2PTGIRGSK3B | |
| SCHEMBL459470 | 0.74 | KMT2A (0.70) | ALDH1A1LMNARAB9AKMT2AHDAC3 | |
| SCHEMBL18723690 | 0.73 | TDP1 (0.47) | ALDH1A1HTTKMT2AMEN1AKR1B1 | |
| SCHEMBL28091696 | 0.73 | RAPGEF4 (0.64) | ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL28061534 | 0.73 | PTGIR (0.41) | ALDH1A1LMNAHTTRAB9AKMT2A | |
| SCHEMBL18723828 | 0.72 | PTGS1 (0.41) | ALDH1A1LMNAHTTKMT2AMEN1 | |
| Butane SCHEMBL10982980 | 0.71 | KMT2A (0.66) | ALDH1A1LMNARAB9AKMT2AHDAC3 | |
| SCHEMBL27677668 | 0.71 | PPARA (0.42) | ALDH1A1KMT2AMEN1MAPTPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906617-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-104254534-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-105906617-A | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-103038231-B | Modulators of HEC1 activity and methods thereof | Taivex Therapeutics Corp. (CN) | 2016-04-20 | — | — | CN | disclosed |