Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27898778 | 0.87 | MTNR1B (0.52) | PPARAALDH1A1LMNAARMTNR1A | |
| SCHEMBL27916437 | 0.86 | PPARA (0.50) | PPARAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7561681 | 0.83 | KMT2A (0.47) | KMT2ALMNAARHDAC3HDAC4 | |
| SCHEMBL9720532 | 0.81 | ALDH1A1 (0.61) | PPARAKMT2AMEN1ALDH1A1PPARG | |
| SCHEMBL27898929 | 0.81 | PPARA (0.50) | PPARAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11955348 | 0.80 | KMT2A (0.64) | KMT2AALDH1A1LMNARAB9AHDAC3 | |
| SCHEMBL28061523 | 0.78 | ALDH1A1 (0.46) | PPARAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL459470 | 0.77 | KMT2A (0.70) | KMT2AALDH1A1LMNARAB9AHDAC3 | |
| SCHEMBL28091696 | 0.77 | RAPGEF4 (0.64) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL11527000 | 0.75 | ESR1 (0.46) | KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906617-A | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-103038231-B | Modulators of HEC1 activity and methods thereof | Taivex Therapeutics Corp. (CN) | 2016-04-20 | — | — | CN | disclosed |
| CN-104254534-A | Modulators of HEC1 activity and methods thereof | TAIVEX THERAPEUTICS CORP | 2014-12-31 | — | — | CN | disclosed |
| CN-103038231-A | Modulators of HEC1 activity and methods thereof | TAIVEX THERAPEUTICS INC | 2013-04-10 | — | — | CN | disclosed |