Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28061512 | 0.91 | S1PR2 (0.34) | S1PR2S1PR1S1PR3LPAR2MAPT | |
| SCHEMBL13313279 | 0.76 | KMT2A (0.49) | MAPTL3MBTL1KMT2AMEN1KDM4E | |
| SCHEMBL27986851 | 0.75 | S1PR1 (0.38) | S1PR2S1PR1S1PR3LPAR2MAPT | |
| SCHEMBL27986850 | 0.75 | S1PR1 (0.41) | S1PR2S1PR1S1PR3LPAR2KMT2A | |
| SCHEMBL28091410 | 0.74 | MAPT (0.35) | S1PR2S1PR1S1PR3LPAR2MAPT | |
| SCHEMBL13349221 | 0.73 | KMT2A (0.37) | S1PR2S1PR1S1PR3LPAR2MAPT | |
| SCHEMBL13313284 | 0.73 | LMNA (0.53) | MAPTL3MBTL1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28042959 | 0.72 | ALDH1A1 (0.53) | MAPTSCN8ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28091413 | 0.72 | SCN4A (0.42) | MAPTSCN8AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL6132273 | 0.72 | KDM4E (0.54) | S1PR2S1PR1S1PR3LPAR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906617-A | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-103038231-B | Modulators of HEC1 activity and methods thereof | Taivex Therapeutics Corp. (CN) | 2016-04-20 | — | — | CN | disclosed |