Known targets — ChEMBL curated mechanism
S1PR1S1PR2S1PR3S1PR4S1PR5rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 known ✓ | Q99500 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799155 | 0.82 | GPR35 (0.55) | TSHRHCAR3MEN1KMT2AESR1 | |
| SCHEMBL3799151 | 0.74 | GPR35 (0.56) | TSHRMEN1KMT2AESR1CA12 | |
| SCHEMBL3931562 | 0.74 | MEN1 (0.55) | S1PR3AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL28270647 | 0.73 | ALDH1A1 (0.68) | TSHRESR1KDM4E | |
| Salicylic Acid SCHEMBL8420136 | 0.73 | NAAA (0.50) | S1PR3TSHRPLK1MEN1KMT2A | |
| Phosphoric Acid SCHEMBL11199365 | 0.72 | CA1 (0.53) | TSHRCA12CA9 | |
| SCHEMBL3671 | 0.72 | TSHR (0.68) | TSHRMEN1KMT2AKDM4E | |
| SCHEMBL30893562 | 0.72 | TSHR (0.68) | TSHRMEN1KMT2AKDM4E | |
| SCHEMBL16267318 | 0.71 | TSHR (0.66) | TSHRMEN1KMT2AKDM4E | |
| Potassium Ion SCHEMBL16267317 | 0.71 | TSHR (0.66) | TSHRMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105848658-A | Combination of 6-oxo-1, 6-dihydro-pyridazine derivatives with anti-cancer activity and gefitinib | 默克专利股份公司 | 2016-08-10 | — | — | CN | disclosed |