Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 3/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27882555 | 0.88 | MPO (0.47) | TSHRMPOPOLBSLC1A1KDM4E | |
| SCHEMBL28188511 | 0.84 | BACE1 (0.33) | BACE1LMNAHTT | |
| SCHEMBL26999351 | 0.82 | POLB (0.44) | TSHRGABRA1GABRB2POLBMEN1 | |
| SCHEMBL28116428 | 0.80 | KEAP1 (0.41) | TSHRGABRA1GABRB2POLBKDM4E | |
| SCHEMBL28837424 | 0.79 | ENPP2 (0.40) | KDM4E | |
| SCHEMBL27882499 | 0.77 | MPO (0.42) | TSHRGABRA1GABRB2MPOKDM4E | |
| SCHEMBL28065773 | 0.77 | TSHR (0.40) | TSHRGABRA1GABRB2MPOPOLB | |
| SCHEMBL28983105 | 0.73 | TSHR (0.44) | TSHRGABRA1GABRB2POLBTRIM24 | |
| SCHEMBL7260358 | 0.73 | GABRA1 (0.37) | TSHRGABRA1GABRB2CNR1CNR2 | |
| SCHEMBL27893496 | 0.72 | TSHR (0.42) | TSHRGABRA1GABRB2POLBTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801550-A | Novel benzopyran kinase modulators | 理森制药股份公司 | 2016-07-27 | — | — | CN | claimed |
| CN-105801550-B | Novel chromene kinase modulator | 理森制药股份公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-105801550-A | Novel benzopyran kinase modulators | 理森制药股份公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-102812013-B | Novel benzopyran kinase modulators | RHIZEN PHARMACEUTICALS S.A. (CH) | 2016-05-25 | — | — | CN | disclosed |