Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2698219 | 0.79 | ALDH1A1 (0.43) | METALDH1A1GLAHPGDKDM4E | |
| SCHEMBL187290 | 0.78 | CBFB (0.57) | METALDH1A1GLAHPGDF2 | |
| SCHEMBL27856123 | 0.76 | ALDH1A1 (0.46) | METALDH1A1GLAHPGDKDM4E | |
| SCHEMBL359222 | 0.76 | MET (0.47) | METALDH1A1GLAHPGDF2 | |
| SCHEMBL370132 | 0.76 | CBFB (0.46) | METALDH1A1GLAHPGDF2 | |
| SCHEMBL359221 | 0.73 | ALDH1A1 (0.50) | METALDH1A1GLAHPGDGAA | |
| SCHEMBL358992 | 0.73 | EGFR (0.42) | METALDH1A1GLAHPGDKDM4E | |
| SCHEMBL2697677 | 0.71 | PTGS1 (0.66) | METALDH1A1GLAHPGDKDM4E | |
| SCHEMBL187431 | 0.70 | FBP1 (0.44) | METALDH1A1GLAHPGDF2 | |
| SCHEMBL358693 | 0.70 | CNR1 (0.47) | METALDH1A1GLAHPGDF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007125-B | fused heterocyclic derivatives and methods of use | AMGEN INC. (US) | 2016-05-25 | — | — | CN | disclosed |