Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187290 | 0.89 | CBFB (0.57) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL3839961 | 0.86 | ALDH1A1 (0.51) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL359222 | 0.81 | MET (0.47) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL358693 | 0.77 | CNR1 (0.47) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL187431 | 0.77 | FBP1 (0.44) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL358992 | 0.77 | EGFR (0.42) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL359885 | 0.77 | MET (0.42) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL13619702 | 0.77 | MET (0.42) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL2698219 | 0.77 | ALDH1A1 (0.43) | CBFBMETALDH1A1F2GLA | |
| SCHEMBL28065817 | 0.76 | MET (0.45) | CBFBMETALDH1A1F2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |
| EP-2310389-A1 | HETEROCYCLES AS PROTEIN KINASE INHIBITORS | Amgen Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| WO-2009143477-A1 | HETEROCYCLES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2009-11-26 | — | — | WO | disclosed |