Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.47 |
| ▸ | CBFB | Q13951 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187290 | 0.83 | CBFB (0.57) | METCBFBALDH1A1F2GLA | |
| SCHEMBL186997 | 0.82 | FDPS (0.43) | METCBFBALDH1A1F2GLA | |
| SCHEMBL370132 | 0.81 | CBFB (0.46) | METCBFBALDH1A1F2GLA | |
| SCHEMBL187431 | 0.77 | FBP1 (0.44) | METCBFBALDH1A1F2GLA | |
| SCHEMBL358693 | 0.77 | CNR1 (0.47) | METCBFBALDH1A1F2GLA | |
| SCHEMBL358992 | 0.77 | EGFR (0.42) | METCBFBALDH1A1F2GLA | |
| SCHEMBL13619702 | 0.77 | MET (0.42) | METCBFBALDH1A1F2GLA | |
| SCHEMBL359885 | 0.77 | MET (0.42) | METCBFBALDH1A1F2GLA | |
| SCHEMBL2698219 | 0.77 | ALDH1A1 (0.43) | METCBFBALDH1A1F2GLA | |
| SCHEMBL186985 | 0.77 | PDGFRB (0.43) | METCBFBALDH1A1F2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |