Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27460564 | 0.87 | HTT (0.39) | HTTLMNAKDM4EMITFALDH1A1 | |
| SCHEMBL27815106 | 0.87 | CYP4F2 (0.51) | HTTLMNACYP4F2CYP4A11MEN1 | |
| SCHEMBL27673408 | 0.85 | HTT (0.42) | HTTLMNAKDM4EMITFALDH1A1 | |
| SCHEMBL22596494 | 0.83 | CYP4F2 (0.55) | HTTKDM4EMITFALDH1A1CYP4F2 | |
| SCHEMBL28033799 | 0.83 | TNKS2 (0.46) | HTTLMNAKDM4EMITFALDH1A1 | |
| SCHEMBL30073969 | 0.78 | ABL1 (0.38) | ALDH1A1CYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL5197975 | 0.77 | DGAT1 (0.55) | HTTLMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL6172318 | 0.77 | CES2 (0.45) | KDM4EALDH1A1FAAHMEN1KMT2A | |
| SCHEMBL28798095 | 0.76 | PTGDR2 (0.44) | LMNAKDM4EALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL28872332 | 0.76 | FAAH (0.41) | HTTKDM4EMITFALDH1A1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563043-B | Substituted pyridines as inhibitors of DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-110402249-A | Extracellular nucleotides enzyme inhibitor and its application method | CALITHERA BIOSCIENCES INC | 2019-11-01 | — | — | CN | disclosed |
| CN-110234656-A | Extracellular nucleotides enzyme inhibitor and its application method | 卡利泰拉生物科技公司 | 2019-09-13 | — | — | CN | disclosed |
| CN-106232584-B | As 6 inhibitor of histone deacetylase new compound and include its pharmaceutical composition | 株式会社钟根堂 | 2019-06-28 | — | — | CN | disclosed |
| CN-109310679-A | Combination comprising histone deacetylase inhibitor | 卡鲁斯治疗有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-108348523-A | Compositions comprising PI3K inhibitors and HDAC inhibitors | 卡鲁斯治疗有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-105358550-B | Histone deacetylase inhibitors | 卡鲁斯治疗有限公司 | 2018-04-06 | — | — | CN | disclosed |
| CN-105283439-B | The dibenzoylhydrazine of boracic | 英特瑞克斯顿股份有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-103261156-B | For treating the noval chemical compound of neurodegenerative disease | 鲁汶天主教大学研究开发部 | 2016-12-28 | — | — | CN | disclosed |
| CN-106232584-A | As the new compound of histone deacetylase 6 inhibitor and the pharmaceutical composition comprising it | 株式会社钟根堂 | 2016-12-14 | — | — | CN | disclosed |
| CN-104230827-B | 1-(aryl methyl) quinazoline-2,4 (1H, 3H)-diketone is as PARP inhibitor and application thereof | 南京英派药业有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-105593211-A | Indol and indazol derivatives | HOFFMANN LA ROCHE | 2016-05-18 | — | — | CN | disclosed |