SCHEMBL28069869

SCHEMBL28069869

[O-][S+](c1ccc(F)cc1)C(F)F

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.32
CA2 P00918 3/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
ACHE P22303 1/20 0.32
FBP1 P09467 1/20 0.30
IDO1 P14902 1/20 0.30
TDO2 P48775 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13851039 0.78 ACHE (0.36) CA1CA2CA7CA9ACHE
SCHEMBL776881 0.77
SCHEMBL19567347 0.73 ALDH1A1 (0.36) CA1CA2CA9
SCHEMBL28379149 0.73 CA1 (0.46) CA1CA2CA7CA9ACHE
SCHEMBL776183 0.73 CA1 (0.38) CA1CA2CA7CA9ACHE
SCHEMBL16555573 0.70 VCP (0.34)
SCHEMBL11754390 0.69 MMP1 (0.39) CA1CA2
SCHEMBL19823499 0.69 LOXL2 (0.36) CA1CA2CA7CA9ACHE
SCHEMBL14467510 0.69 ACHE (0.41) CA1CA2CA7CA9ACHE
SCHEMBL13823044 0.69 CA1 (0.35) CA1CA2CA7CA9ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110981768-A Simple synthesis method of aryl difluoroalkyl sulfoxide compound 山东理工大学 2020-04-10 CN disclosed
CN-105530923-A Aryl ethers and their use PELOTON THERAPEUTICS INC 2016-04-27 CN disclosed