Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NTMT1 | Q9BV86 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28070620 | 0.82 | MAPT (0.41) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL28070569 | 0.82 | MAPT (0.41) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL16522584 | 0.79 | CTSK (0.42) | PIM2 | |
| SCHEMBL27960218 | 0.76 | CHRNB2 (0.49) | RAB9AMAPTALDH1A1POLBCYP2C9 | |
| SCHEMBL16505918 | 0.76 | ALDH1A1 (0.39) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL16505919 | 0.76 | ALDH1A1 (0.39) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL28070539 | 0.76 | MAPT (0.45) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL27925369 | 0.76 | MAPT (0.54) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL19371093 | 0.75 | BTK (0.48) | MEN1KMT2AALDH1A1 | |
| SCHEMBL28070486 | 0.74 | MAPT (0.41) | MEN1KMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658653-A | Furo- and thieno-pyridine carboxamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2016-06-08 | — | — | CN | disclosed |