Water

Water

SCHEMBL28070530

O.O=S(=O)(O)C=Cc1ccccc1.[LiH]

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 known ✓ O15379 1/20 0.45
HDAC4 known ✓ P56524 1/20 0.45
HDAC1 known ✓ Q13547 1/20 0.45
HDAC7 known ✓ Q8WUI4 1/20 0.45
HDAC2 known ✓ Q92769 1/20 0.45
HDAC10 known ✓ Q969S8 1/20 0.45
HDAC11 known ✓ Q96DB2 1/20 0.45
HDAC8 known ✓ Q9BY41 1/20 0.45
HDAC6 known ✓ Q9UBN7 1/20 0.45
HDAC9 known ✓ Q9UKV0 1/20 0.45
HDAC5 known ✓ Q9UQL6 1/20 0.45
PPARG P37231 6/20 0.50
LMNA P02545 2/20 0.50
NFE2L2 Q16236 2/20 0.50
HTT P42858 1/20 0.46
TNKS O95271 1/20 0.45
HCAR2 Q8TDS4 1/20 0.45
TNKS2 Q9H2K2 1/20 0.45
PLIN1 O60240 1/20 0.45
ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL27741929 0.98 PPARG (0.52) PPARGLMNANFE2L2HTTHDAC3
SCHEMBL28093141 0.98 PPARG (0.52) PPARGLMNANFE2L2HTTHDAC3
SCHEMBL193642 0.98 PPARG (0.52) PPARGLMNANFE2L2HTTHDAC3
Water SCHEMBL2263066 0.96 PPARG (0.50) PPARGLMNANFE2L2HTTHDAC3
SCHEMBL15001 0.96 PPARG (0.53) PPARGLMNANFE2L2HTTHDAC3
SCHEMBL1201904 0.96 PPARG (0.53) PPARGLMNANFE2L2HTTHDAC3
SCHEMBL2496181 0.96 PPARG (0.53) PPARGLMNANFE2L2HTTHDAC3
SCHEMBL6438105 0.93 PPARG (0.52) PPARGLMNANFE2L2HTTHDAC3
Phosphine SCHEMBL8861826 0.93 PPARG (0.52) PPARGLMNANFE2L2HTTHDAC3
Hydrochloric Acid SCHEMBL1877961 0.93 PPARG (0.52) PPARGLMNANFE2L2HTTHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105960393-A lithium styrene sulfonate 东曹株式会社 2016-09-21 CN disclosed