SCHEMBL28070945

SCHEMBL28070945

FC(F)(F)c1c[nH]c(Cl)c1

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
TSHR P16473 2/20 0.33
HPGD P15428 2/20 0.33
CYP3A4 P08684 1/20 0.33
ALOX15 P16050 1/20 0.33
HIF1A Q16665 1/20 0.33
TXNRD1 Q16881 1/20 0.33
TXNRD3 Q86VQ6 1/20 0.33
TXNRD2 Q9NNW7 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HSD17B10 Q99714 1/20 0.33
AHR P35869 1/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PDE2A O00408 1/20 0.31
DAO P14920 1/20 0.30
CES2 O00748 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21719649 0.75 GABRA1 (0.33) ALDH1A1HPGDALOX15TDP1HSD17B10
SCHEMBL6986501 0.73 DAO (0.40) ALDH1A1HPGDHSD17B10MEN1KMT2A
SCHEMBL9224370 0.72 KDM4E (0.33) ALDH1A1TSHRHPGDHSD17B10MEN1
SCHEMBL28222880 0.70 TSHR (0.38) ALDH1A1TSHRHPGDHSD17B10MEN1
SCHEMBL28579313 0.70 LMNA (0.33) ALDH1A1TSHRHPGDMEN1KMT2A
SCHEMBL29291942 0.70 MEN1 (0.31) ALDH1A1TSHRHPGDMEN1KMT2A
SCHEMBL17002554 0.65 MEN1 (0.48) ALDH1A1HPGDHSD17B10MEN1KMT2A
SCHEMBL21793221 0.65 RAF1 (0.33) ALDH1A1TSHRHPGDCYP3A4MEN1
SCHEMBL28090101 0.65 ALDH1A1 (0.37) ALDH1A1HPGDMEN1KMT2APDE2A
SCHEMBL17162885 0.65 MEN1 (0.32) ALDH1A1HPGDHSD17B10MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107151229-A A kind of method for producing the trifluoromethyl pyridine of 2 chlorine 4 内蒙古佳瑞米精细化工有限公司 2017-09-12 CN claimed
CN-110267950-A Substituted heteroaryl pyrrolones and its salt and its purposes as herbicidal active compounds 拜耳作物科学股份公司 2019-09-20 CN disclosed
CN-108929336-A Thiazolopyrimidinone class as the active regulator of nmda receptor 豪夫迈·罗氏有限公司 2018-12-04 CN disclosed
CN-106771303-B One kind is for analyzing conveying device and its working method in heavy metal-polluted soil sample injector 徐州腾睿智能装备有限公司 2018-09-18 CN disclosed
CN-105612162-B Thiazolopyrimidinones as modulators of NMDA receptor activity 豪夫迈·罗氏有限公司 2018-08-21 CN disclosed
CN-105764898-A Heterocyclic amide compounds and herbicides 先正达参股股份有限公司 2016-07-13 CN disclosed