SCHEMBL2807136

SCHEMBL2807136

Cc1cc(C(=O)O)oc(=O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 1.00
KDM4E B2RXH2 3/20 1.00
MAPT P10636 2/20 0.63
RAB9A P51151 2/20 0.57
NPC1 O15118 1/20 0.57
CA1 P00915 1/20 0.52
CA9 Q16790 1/20 0.52
APEX1 P27695 1/20 0.43
TPMT P51580 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
DAO P14920 1/20 0.42
HCAR2 Q8TDS4 1/20 0.41
ALDH1A1 P00352 3/20 0.40
HPGD P15428 3/20 0.40
MEN1 O00255 3/20 0.40
GAA P10253 1/20 0.40
MAPK1 P28482 1/20 0.40
PPARG P37231 1/20 0.40
HTT P42858 1/20 0.40
MAPK10 P53779 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11853770 0.81 KDM4E (0.68) KMT2AKDM4EMAPTRAB9ANPC1
SCHEMBL19303326 0.76 KDM4E (0.61) KMT2AKDM4EMAPTCA1CA9
SCHEMBL1843937 0.76 KDM4E (0.61) KMT2AKDM4EMAPTCA1CA9
SCHEMBL11864019 0.75 KMT2A (0.60) KMT2AKDM4EMAPTRAB9ANPC1
SCHEMBL25171055 0.74 KDM4E (0.59) KMT2AKDM4ERAB9ANPC1DAO
SCHEMBL22345883 0.74 KDM4E (0.59) KMT2AKDM4EMAPTCA1CA9
SCHEMBL27909286 0.70
SCHEMBL1176813 0.70 NQO1 (0.58) KMT2AKDM4EMAPTCA1CA9
SCHEMBL11861615 0.69 KDM4E (0.53) KMT2AKDM4EMAPTRAB9ANPC1
SCHEMBL25167828 0.69 KDM4E (0.53) KMT2AKDM4EMAPTRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US claimed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US claimed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US claimed
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US disclosed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US disclosed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US disclosed
US-20090028807-A1 COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION L'OREAL (FR) 2009-01-29 US disclosed
US-3969323-A Photo-crosslinkable 2-pyrone polymers and processes for the manufacture thereof HOECHST AKTIENGESELLSCHAFT (DT) 1976-07-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS CUTA, SUCLG1, KRT18 KMT2A 2242/4885KDM4E 2504/4885MAPT 2575/4885
US-20090028807-A1 COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION CUTA, SYMPK, TPRKB KMT2A 2544/4885KDM4E 1615/4885MAPT 2140/4885
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT ACMSD, CUTA, PCCA KMT2A 1122/4885KDM4E 1109/4885MAPT 3115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.