Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tranexamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG known ✓ | P00747 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | PLAT | P00750 | 1/20 | 0.80 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tranexamic Acid SCHEMBL675990 | 0.91 | LMNA (0.67) | PLGLMNAPLATANPEPENPEP | |
| Tranexamic Acid SCHEMBL15902803 | 0.91 | LMNA (0.67) | PLGLMNAPLATANPEPENPEP | |
| Tranexamic Acid SCHEMBL1404323 | 0.91 | LMNA (0.67) | PLGLMNAPLATANPEPENPEP | |
| SCHEMBL9456678 | 0.89 | LMNA (0.60) | PLGLMNAPLATANPEPENPEP | |
| Tranexamic Acid SCHEMBL423790 | 0.89 | PLG (1.00) | PLGLMNAPLATANPEPENPEP | |
| Tranexamic Acid SCHEMBL186034 | 0.89 | PLG (1.00) | PLGLMNAPLATANPEPENPEP | |
| Tranexamic Acid SCHEMBL349408 | 0.89 | PLG (1.00) | PLGLMNAPLATANPEPENPEP | |
| SCHEMBL7055722 | 0.89 | LMNA (0.60) | PLGLMNAPLATANPEPENPEP | |
| Tranexamic Acid SCHEMBL322487 | 0.89 | PLG (1.00) | PLGLMNAPLATANPEPENPEP | |
| Tranexamic Acid SCHEMBL16974 | 0.89 | PLG (1.00) | PLGLMNAPLATANPEPENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829446-B | Polyester compositions with improved whiteness | 索尔维特殊聚合物美国有限责任公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-105829446-A | Polyester compositions with improved whiteness | 索尔维特殊聚合物美国有限责任公司 | 2016-08-03 | — | — | CN | disclosed |