Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tranexamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG known ✓ | P00747 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | PLAT | P00750 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tranexamic Acid SCHEMBL1404323 | 1.00 | LMNA (0.67) | LMNAPLGPLATTHRBKMT2A | |
| Tranexamic Acid SCHEMBL15902803 | 1.00 | LMNA (0.67) | LMNAPLGPLATTHRBKMT2A | |
| Adipic Acid SCHEMBL6901707 | 0.91 | LMNA (0.68) | LMNAPLGPLATTHRBKMT2A | |
| Tranexamic Acid SCHEMBL28072610 | 0.91 | PLG (0.80) | LMNAPLGPLATTHRBKMT2A | |
| Tranexamic Acid SCHEMBL5321519 | 0.84 | PLG (0.48) | LMNAPLGPLATTHRBKMT2A | |
| Adipic Acid SCHEMBL11871671 | 0.84 | LMNA (0.58) | LMNAPLGPLATTHRBKMT2A | |
| SCHEMBL7055722 | 0.82 | LMNA (0.60) | LMNAPLGPLATTHRBKMT2A | |
| SCHEMBL9456678 | 0.82 | LMNA (0.60) | LMNAPLGPLATTHRBKMT2A | |
| Sebacic Acid SCHEMBL8982028 | 0.82 | TSHR (0.60) | LMNAPLGPLATTHRBKMT2A | |
| Tranexamic Acid SCHEMBL322487 | 0.82 | PLG (1.00) | LMNAPLGPLATKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010143-A1 | ADHESIVE HEMOSTATIC AGENT BASED ON PORCINE ATELOCOLLAGEN AND METHOD FOR PRODUCTION THEREOF | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONGSEI-UNIVERSITY (KR) | 2012-01-12 | — | — | US | disclosed |
| US-8067374-B2 | Adhesive hemostatic agent based on porcine atelocollagen and method for production thereof | DALIM BIOTECH CO., LTD. (KR) | 2011-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010143-A1 | ADHESIVE HEMOSTATIC AGENT BASED ON PORCINE ATELOCOLLAGEN AND METHOD FOR PRODUCTION THEREOF | PIGS, COL14A1, COL1A1 | PLG 124/4885LMNA 1764/4885PLAT 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.