Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27403683 | 0.68 | ADRA2A (0.33) | MAPTNPC1 | |
| SCHEMBL16676455 | 0.68 | CYP3A4 (0.40) | SMN1; SMN2MAPTNPC1RAB9ADDR1 | |
| SCHEMBL3795007 | 0.67 | HPGD (0.41) | SMN1; SMN2NPC1RAB9ADDR1 | |
| SCHEMBL3781267 | 0.67 | SLC6A2 (0.51) | SMN1; SMN2MAPTLMNA | |
| SCHEMBL18793099 | 0.66 | ITGB2 (0.47) | SMN1; SMN2MAPTNPC1LMNARAB9A | |
| SCHEMBL8492081 | 0.64 | CYP3A4 (0.45) | SMN1; SMN2MAPTNPC1LMNARAB9A | |
| SCHEMBL9461295 | 0.64 | ALDH1A1 (0.55) | MAPTLMNA | |
| SCHEMBL1196194 | 0.64 | DDR1 (0.40) | SMN1; SMN2MAPTLMNADDR1 | |
| SCHEMBL3789429 | 0.63 | CYP3A4 (0.48) | SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8469732 | 0.63 | CES2 (0.48) | SMN1; SMN2MAPTNPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829285-A | Quinazolinone and isoquinolinone derivatives | 中外制药株式会社 | 2016-08-03 | — | — | CN | disclosed |