Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | TRPV3 | Q8NET8 | 9/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28864065 | 0.80 | KDM4E (0.46) | KCNH2TRPV3PIK3CATRPV4PDE10A | |
| SCHEMBL28074571 | 0.74 | TRPV4 (0.42) | KCNH2TRPV3MAP4K4PIK3CAMINK1 | |
| SCHEMBL16635373 | 0.73 | KCNH2 (0.42) | KCNH2TRPV3MAP4K4PIK3CAMINK1 | |
| SCHEMBL21716199 | 0.73 | KCNH2 (0.48) | KCNH2TRPV3MAP4K4PIK3CAMINK1 | |
| SCHEMBL17518816 | 0.73 | TRPV3 (0.44) | KCNH2TRPV3MAP4K4PIK3CAMINK1 | |
| SCHEMBL790022 | 0.71 | HSP90AA1 (0.35) | — | |
| SCHEMBL13680557 | 0.71 | TRPV3 (0.51) | KCNH2TRPV3 | |
| SCHEMBL12538145 | 0.71 | TRPV3 (0.54) | KCNH2TRPV3TRPV4 | |
| SCHEMBL16647793 | 0.70 | TRPA1 (0.46) | KCNH2TRPV3MAP4K4PIK3CAMINK1 | |
| Hydrochloric Acid SCHEMBL28242155 | 0.70 | TRPV3 (0.43) | KCNH2TRPV3MAP4K4PIK3CAMINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105612153-B | Substituted heterocyclic sulfonamide compound as TRPA1 conditioning agents | 豪夫迈·罗氏有限公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-105612153-A | Substituted sulfonamide compounds as TRPA1 conditioner | HOFFMANN LA ROCHE | 2016-05-25 | — | — | CN | disclosed |