Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16538344 | 0.78 | KIF11 (0.42) | ABL1BCR | |
| SCHEMBL29446490 | 0.75 | ABL1 (0.49) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL28242951 | 0.74 | TRPV4 (0.42) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL28074496 | 0.74 | KCNH2 (0.42) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL28863764 | 0.73 | ABL1 (0.48) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL28242166 | 0.72 | CYP11B2 (0.47) | — | |
| SCHEMBL1202858 | 0.72 | RAB9A (0.36) | MAP4K4 | |
| SCHEMBL16906526 | 0.71 | ABL1 (0.46) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL28155918 | 0.71 | ABL1 (0.46) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL16894253 | 0.71 | ABL1 (0.46) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105612153-B | Substituted heterocyclic sulfonamide compound as TRPA1 conditioning agents | 豪夫迈·罗氏有限公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-105612153-A | Substituted sulfonamide compounds as TRPA1 conditioner | HOFFMANN LA ROCHE | 2016-05-25 | — | — | CN | disclosed |