Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3834757 | 0.85 | RAPGEF4 (0.65) | RAPGEF4ALDH3A1PKMALDH1A1HTT | |
| SCHEMBL1599348 | 0.83 | HTR6 (0.50) | RAPGEF4PPME1TSHRMEN1KMT2A | |
| SCHEMBL11932215 | 0.79 | RAPGEF4 (0.66) | RAPGEF4PKMTSHRMEN1KMT2A | |
| SCHEMBL28458237 | 0.78 | RAPGEF4 (0.52) | RAPGEF4ALDH3A1PKMLMNAHTT | |
| SCHEMBL3968075 | 0.76 | PPME1 (0.55) | RAPGEF4ALDH3A1PKMPPME1MEN1 | |
| SCHEMBL30427800 | 0.76 | HTR6 (0.52) | ALDH3A1PKMPPME1TSHRMEN1 | |
| SCHEMBL5535689 | 0.75 | RAPGEF4 (0.61) | RAPGEF4ALDH3A1PKMALDH1A1HTT | |
| SCHEMBL13381696 | 0.72 | KDM4E (0.53) | ALDH3A1TSHRKMT2AALDH1A1HTT | |
| SCHEMBL30041811 | 0.70 | HTR6 (0.53) | RAPGEF4ALDH3A1KMT2AALDH1A1LMNA | |
| SCHEMBL3967709 | 0.69 | HTR6 (0.75) | RAPGEF4ALDH3A1PKMTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105612153-B | Substituted heterocyclic sulfonamide compound as TRPA1 conditioning agents | 豪夫迈·罗氏有限公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-105612153-A | Substituted sulfonamide compounds as TRPA1 conditioner | HOFFMANN LA ROCHE | 2016-05-25 | — | — | CN | disclosed |