Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 10/20 | 0.55 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APEH | P13798 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616366 | 0.84 | PPME1 (0.60) | PPME1APEHMEN1KMT2ATRIM24 | |
| SCHEMBL2457308 | 0.83 | RAPGEF4 (0.58) | PPME1ALDH3A1PKMAPEHMMP2 | |
| SCHEMBL3964674 | 0.83 | PPME1 (0.58) | PPME1ALDH3A1PKMAPEHMMP2 | |
| SCHEMBL3967048 | 0.83 | PPME1 (0.43) | PPME1APEHRAPGEF4HTR6 | |
| SCHEMBL3964676 | 0.80 | PPME1 (0.45) | PPME1APEHRAPGEF4TRIM24TRIM33 | |
| SCHEMBL3969689 | 0.80 | PPME1 (0.64) | PPME1APEH | |
| SCHEMBL3969097 | 0.79 | NOD1 (0.43) | PPME1APEHMMP2MEN1KMT2A | |
| SCHEMBL6419604 | 0.78 | PPME1 (0.67) | PPME1PKMRAPGEF4TRIM24TRIM33 | |
| SCHEMBL28074550 | 0.76 | RAPGEF4 (0.49) | PPME1ALDH3A1PKMMMP2MEN1 | |
| SCHEMBL3966831 | 0.73 | MET (0.49) | PPME1PKMMMP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |