Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15784421 | 0.90 | ALDH1A1 (0.48) | TDP1ALOX5CA1CA2CHEK1 | |
| SCHEMBL28564302 | 0.85 | MAOA (0.46) | TDP1ALOX5KMT2AMEN1L3MBTL1 | |
| SCHEMBL10061664 | 0.79 | PDPK1 (0.55) | ALOX5CA1CA2GSK3BPDPK1 | |
| SCHEMBL2121701 | 0.77 | TDP1 (0.49) | TDP1CA2KDRFLT3GSK3B | |
| SCHEMBL2121696 | 0.77 | TDP1 (0.49) | TDP1CA2KDRFLT3GSK3B | |
| SCHEMBL18209554 | 0.76 | ALOX5 (0.47) | TDP1ALOX5CHEK1ROCK2CSF1R | |
| SCHEMBL30183643 | 0.76 | TGM2 (0.51) | TDP1ALOX5CA1CA2ROCK2 | |
| SCHEMBL20594709 | 0.76 | TGM2 (0.51) | TDP1ALOX5CA1CA2ROCK2 | |
| SCHEMBL15783957 | 0.75 | ALDH1A1 (0.48) | TDP1ALOX5CHEK1ROCK2CSF1R | |
| SCHEMBL29846133 | 0.75 | ALDH1A1 (0.48) | TDP1ALOX5CHEK1ROCK2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837493-B | The synthetic method and its intermediate of Nintedanib | 东南大学 | 2018-12-14 | — | — | CN | claimed |
| CN-105837493-A | A synthetic method of Nintedanib and an intermediate of Nintedanib | 东南大学 | 2016-08-10 | — | — | CN | claimed |
| CN-105837493-B | The synthetic method and its intermediate of Nintedanib | 东南大学 | 2018-12-14 | — | — | CN | disclosed |
| CN-105837493-A | A synthetic method of Nintedanib and an intermediate of Nintedanib | 东南大学 | 2016-08-10 | — | — | CN | disclosed |