Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | SOD3 | P08294 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75314 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL27901405 | 0.84 | — | — | |
| SCHEMBL2551980 | 0.77 | KMT2A (0.40) | KMT2ARAB9AMAPTNPC1KEAP1 | |
| Boric Acid SCHEMBL17848604 | 0.77 | NOS1 (0.42) | KMT2ARAB9AMAPTNPC1KEAP1 | |
| Phosphoric Acid SCHEMBL7647885 | 0.74 | RAB9A (0.42) | KMT2ARAB9AMAPTNPC1KEAP1 | |
| Formamide SCHEMBL10967419 | 0.74 | KEAP1 (0.39) | KMT2ARAB9AMAPTNPC1KEAP1 | |
| SCHEMBL27487661 | 0.72 | KMT2A (0.45) | KMT2ARAB9AMAPTNPC1KEAP1 | |
| Pyridine SCHEMBL28098609 | 0.72 | KMT2A (0.45) | KMT2ARAB9AMAPTNPC1KEAP1 | |
| SCHEMBL1425947 | 0.72 | CHRNB2 (0.41) | KMT2AMAPTALDH1A1GABRA1GABRB2 | |
| SCHEMBL20292039 | 0.72 | DDB1 (0.46) | KMT2ARAB9ANPC1KEAP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108138081-A | Spice composition | 奇华顿股份有限公司 | 2018-06-08 | — | — | CN | claimed |
| CN-105842377-A | High performance liquid chromatography detection method for pyrazine compounds in Baijiu | 贵州省产品质量监督检验院 | 2016-08-10 | — | — | CN | claimed |
| CN-110072510-A | Fragrance and flavor material | 高砂香料工业株式会社 | 2019-07-30 | — | — | CN | disclosed |
| CN-110072512-A | Fragrance and flavor material | 高砂香料工业株式会社 | 2019-07-30 | — | — | CN | disclosed |
| CN-109438369-A | A kind of preparation method of Acipimox | 鲁南制药集团股份有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-109222209-A | A kind of compound peppermint cigarette and preparation method thereof | 广东省生物工程研究所（广州甘蔗糖业研究所） | 2019-01-18 | — | — | CN | disclosed |
| CN-109077287-A | A kind of potato essence base-material and potato essence | 增城华栋调味品有限公司 | 2018-12-25 | — | — | CN | disclosed |
| CN-108753862-A | A method of continuously fermented using recombination bacillus coli and prepares 5-Methylpyrazine-2-carboxylic acid | 泰州市惠利生物科技有限公司 | 2018-11-06 | — | — | CN | disclosed |
| CN-103309182-B | Electrophtography photosensor, handle box, image forming apparatus and image forming method | 富士施乐株式会社 | 2018-10-09 | — | — | CN | disclosed |
| CN-105842377-B | The high-efficiency liquid chromatography method for detecting of pyrazine compounds in a kind of white wine | 贵州省产品质量监督检验院 | 2018-03-20 | — | — | CN | disclosed |
| CN-107797381-A | Coloring composition and compound | 住友化学株式会社 | 2018-03-13 | — | — | CN | disclosed |
| CN-105595405-B | Method for promoting sensory quality of tobacco leaves by regulating and controlling content of alkaline flavor components | 广西中烟工业有限责任公司 | 2017-05-03 | — | — | CN | disclosed |