Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Xanthone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.75 |
| ▸ | MAOA | P21397 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.69 |
| ▸ | CASP1 | P29466 | 1/20 | 0.69 |
| ▸ | CASP7 | P55210 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.58 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xanthone SCHEMBL9762833 | 0.89 | MAOA (0.69) | TTRMAOAKDM4EALDH1A1MAPT | |
| SCHEMBL490420 | 0.86 | TTR (1.00) | TTRMAOAKDM4EALDH1A1MAPT | |
| SCHEMBL1787556 | 0.86 | TTR (1.00) | TTRMAOAKDM4EALDH1A1MAPT | |
| Xanthone SCHEMBL28434710 | 0.85 | MAOA (0.95) | TTRMAOAKDM4EALDH1A1MAPT | |
| Xanthone SCHEMBL9738572 | 0.85 | NPC1 (0.73) | TTRMAOAKDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL11367851 | 0.84 | TTR (0.97) | TTRMAOAKDM4EALDH1A1MAPT | |
| Xanthone SCHEMBL18138444 | 0.84 | MAOA (0.75) | TTRMAOAKDM4EALDH1A1MAPT | |
| Xanthone SCHEMBL5842358 | 0.84 | MAOA (0.62) | TTRMAOAKDM4EALDH1A1MAPT | |
| Xanthone SCHEMBL29358061 | 0.83 | MAOA (1.00) | TTRMAOAKDM4EALDH1A1MAPT | |
| Xanthone SCHEMBL29398266 | 0.83 | MAOA (1.00) | TTRMAOAKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103502315-B | Composition and polymer | 旭化成株式会社 | 2016-08-17 | — | — | CN | disclosed |
| CN-105754099-A | Composition and polymer | 旭化成株式会社 | 2016-07-13 | — | — | CN | disclosed |