Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28002712 | 0.81 | TAAR1 (0.35) | IDO1NOTUM | |
| SCHEMBL28002692 | 0.80 | XDH (0.38) | XDH | |
| SCHEMBL28003039 | 0.78 | KDM4E (0.36) | IDO1HTR2CNOTUMMEN1KMT2A | |
| SCHEMBL27817087 | 0.76 | P2RX7 (0.30) | — | |
| SCHEMBL28003061 | 0.69 | CYP2A6 (0.42) | MAPT | |
| SCHEMBL29678302 | 0.68 | TSHR (0.58) | KDM1AIDO1SCN2AHTR2CNOTUM | |
| SCHEMBL1263144 | 0.68 | TSHR (0.58) | KDM1AIDO1SCN2AHTR2CNOTUM | |
| SCHEMBL28002690 | 0.67 | LMNA (0.34) | NOTUMMAPT | |
| SCHEMBL28831583 | 0.67 | NISCH (0.32) | — | |
| SCHEMBL28003002 | 0.67 | CYP1A2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104411709-B | Can be used as imidazo [2, the 1] thiazole-3-ketone derivatives of the diagnostic agent of Alzheimer | 霍夫曼-拉罗奇有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-104411709-A | Imidazo [2,1]thiazol-3-one derivatives useful as diagnostic agents for alzheimer's disease | HOFFMANN LA ROCHE | 2015-03-11 | — | — | CN | disclosed |