Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8490254 | 0.84 | ALDH1A1 (0.42) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| SCHEMBL28389527 | 0.82 | ALOX15 (0.36) | LMNACYP1A2KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL28888291 | 0.82 | ALOX15 (0.39) | LMNACYP1A2KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL27931920 | 0.79 | — | — | |
| SCHEMBL182827 | 0.78 | MAPT (0.46) | LMNAKDM4ESMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL27913846 | 0.77 | HTR2A (0.34) | MEN1HTTKMT2A | |
| SCHEMBL8674 | 0.77 | CA2 (0.46) | LMNACYP1A2KDM4EALDH1A1MAPT | |
| SCHEMBL1062938 | 0.77 | PDE4B (0.36) | LMNACYP1A2KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL12484320 | 0.76 | ALDH1A1 (0.38) | CYP1A2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL14694197 | 0.75 | MCHR1 (0.41) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478497-B | Arylamine derivatives as TTX-S blockers | 拉夸里亚创药株式会社 | 2020-05-08 | — | — | CN | disclosed |
| CN-104520296-B | Pyrrolopyridinone derivatives as TTX-S blocker | 拉夸里亚创药株式会社 | 2016-11-16 | — | — | CN | disclosed |