Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 11/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.42 |
| ▸ | HPGD | P15428 | 9/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.42 |
| ▸ | USP2 | O75604 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29494094 | 0.86 | TSHR (0.41) | CASP1ALDH1A1CYP1A2HSD17B10HPGD | |
| SCHEMBL31148464 | 0.82 | MAPT (0.42) | KDM4ECASP1LMNAALDH1A1CYP1A2 | |
| SCHEMBL3835074 | 0.76 | ATF1 (0.48) | KDM4ECASP1LMNAALDH1A1CYP1A2 | |
| SCHEMBL8900722 | 0.75 | ALDH1A1 (0.42) | KDM4ECASP1LMNAALDH1A1CYP1A2 | |
| SCHEMBL6016398 | 0.75 | ALDH1A1 (0.55) | KDM4ECASP1LMNAALDH1A1CYP1A2 | |
| SCHEMBL9684571 | 0.74 | ADORA3 (0.49) | KDM4ECASP1ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL9685127 | 0.74 | HDAC6 (0.43) | CASP1LMNAALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL9686681 | 0.74 | KDM4E (0.42) | KDM4ECASP1ALDH1A1CYP1A2HSD17B10 | |
| Pipemidic Acid SCHEMBL29351712 | 0.73 | LMNA (0.82) | KDM4ECASP1LMNAALDH1A1HSD17B10 | |
| Pipemidic Acid SCHEMBL135557 | 0.73 | LMNA (0.82) | KDM4ECASP1LMNAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814049-B | Fused tricyclic imdazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-105814049-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |