Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RHEB | Q15382 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28082018 | 0.89 | MAPT (0.66) | HRH4ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL6019366 | 0.79 | POLB (0.64) | HRH4MAPTPOLBKMT2ANPC1 | |
| SCHEMBL28081980 | 0.79 | TP53 (0.69) | ALDH1A1MAPTPOLBKMT2ANPC1 | |
| SCHEMBL28082040 | 0.79 | ALDH1A1 (0.55) | ALDH1A1MAPTOPRM1OPRD1RAD52 | |
| SCHEMBL29732863 | 0.78 | CSNK2A1 (0.58) | ALDH1A1MAPTOPRM1OPRD1RAD52 | |
| SCHEMBL28776019 | 0.78 | CSNK2A1 (0.58) | ALDH1A1MAPTOPRM1OPRD1RAD52 | |
| SCHEMBL23258395 | 0.78 | MEN1 (0.57) | HRH4ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL28082015 | 0.78 | MAOA (0.59) | HRH4ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL6130883 | 0.77 | HRH4 (1.00) | HRH4OPRM1 | |
| SCHEMBL931628 | 0.77 | NHERF1 (0.52) | HRH4POLBKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105820104-B | A kind of indoles -2- amides compound with anti-inflammatory effect and its application in preparing anti-inflammatory drugs | 温州医科大学 | 2018-12-11 | — | — | CN | disclosed |
| CN-105820104-A | Indole-2-acetamide compound with anti-inflammatory effect, and application thereof in preparation of anti-inflammatory drugs | 温州医科大学 | 2016-08-03 | — | — | CN | disclosed |