SCHEMBL2808337

SCHEMBL2808337

NC(=O)CCC(=O)NCCc1ccccc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.67
HDAC3 O15379 2/20 0.64
HDAC1 Q13547 2/20 0.64
HDAC2 Q92769 2/20 0.64
HDAC10 Q969S8 2/20 0.64
HDAC11 Q96DB2 2/20 0.64
HDAC8 Q9BY41 2/20 0.64
HDAC6 Q9UBN7 2/20 0.64
NCOR2 Q9Y618 2/20 0.64
HDAC4 P56524 1/20 0.64
HDAC9 Q9UKV0 1/20 0.64
TAAR1 Q96RJ0 2/20 0.59
ALDH1A1 P00352 1/20 0.57
F13A1 P00488 1/20 0.56
PLAAT5 Q96KN8 1/20 0.56
PLAAT4 Q9UL19 1/20 0.56
EGFR P00533 1/20 0.56
SRC P12931 1/20 0.56
TRPV1 Q8NER1 1/20 0.55
CA12 O43570 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10436247 0.92 HDAC3 (0.74) L3MBTL1HDAC3HDAC1HDAC2HDAC10
SCHEMBL25840478 0.92 HDAC3 (0.77) L3MBTL1HDAC3HDAC1HDAC2HDAC10
SCHEMBL7765076 0.91 L3MBTL1 (0.79) L3MBTL1HDAC3HDAC1HDAC2HDAC10
SCHEMBL7360866 0.90 L3MBTL1 (0.84) L3MBTL1HDAC3HDAC1HDAC2HDAC10
SCHEMBL3825861 0.86 HDAC3 (0.68) L3MBTL1HDAC3HDAC1HDAC2HDAC10
SCHEMBL166980 0.86 L3MBTL1 (0.71) L3MBTL1HDAC3HDAC1HDAC2HDAC10
SCHEMBL15224121 0.86 HDAC3 (0.58) L3MBTL1HDAC3HDAC1HDAC2HDAC10
SCHEMBL2186352 0.85 HDAC2 (0.72) L3MBTL1HDAC3HDAC1HDAC2HDAC10
SCHEMBL24096139 0.85 KDM4E (0.57) ALDH1A1F13A1PLAAT5PLAAT4CA2
Hydrochloric Acid SCHEMBL27811541 0.84 HDAC3 (0.66) L3MBTL1HDAC3HDAC1HDAC2HDAC10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014145390-A1 PLANT GROWTH ENHANCEMENT WITH PESA AND HERBICIDES VALENT BIOSCIENCES CORPORATION (US) 2014-09-18 WO claimed
WO-2021252640-A1 ASPARAGINE DERIVATIVES AND METHODS OF USING SAME SENDA BIOSCIENCES, INC. (US) 2021-12-16 WO disclosed
EP-2439202-B1 INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 SALVAT LAB SA (ES) 2016-04-20 EP disclosed
US-8822452-B2 Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1 LABORATORIOS SALVAT, S.A. (ES) 2014-09-02 US disclosed
US-20130303522-A1 INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 LABORATORIOS SALVAT, S.A. (ES) 2013-11-14 US disclosed
US-8524894-B2 Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1 LABORATORIOS SALVAT, S.A. (ES) 2013-09-03 US disclosed
US-8349593-B2 Process for production of succinic acid amide compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-01-08 US disclosed
US-20100248314-A1 PROCESS FOR PRODUCTION OF SUCCINIC ACID AMIDE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130303522-A1 INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 HSD11B1, HSD17B1, HSD11B2 L3MBTL1 4097/4885HDAC3 1439/4885HDAC1 301/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.