Propyphenazone

Propyphenazone

SCHEMBL28086369

Cc1c(C(C)C)c(=O)n(-c2ccccc2)n1C.Cc1c(N(C)C)c(=O)n(-c2ccccc2)n1C

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.81
ALOX15 P16050 2/20 0.81
CYP1A2 P05177 2/20 0.81
THRB P10828 1/20 0.81
TSHR P16473 1/20 0.81
NAPRT Q6XQN6 1/20 0.81
ADORA3 P0DMS8 1/20 0.78
ALDH1A1 P00352 1/20 0.61
GAA P10253 1/20 0.61
POLB P06746 1/20 0.57
PTGS1 P23219 1/20 0.54
PTGS2 P35354 1/20 0.54
MEN1 O00255 4/20 0.53
KMT2A Q03164 4/20 0.53
MAPT P10636 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
KDM4E B2RXH2 2/20 0.53
ALOX12 P18054 1/20 0.53
USP2 O75604 1/20 0.53
HSD17B10 Q99714 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aminopyrine SCHEMBL1331641 0.90 ALOX15 (1.00) LMNAALOX15CYP1A2THRBTSHR
Aminopyrine SCHEMBL10489978 0.90 ALOX15 (1.00) LMNAALOX15CYP1A2THRBTSHR
Aminopyrine SCHEMBL26293 0.90 ALOX15 (1.00) LMNAALOX15CYP1A2THRBTSHR
Aminopyrine SCHEMBL2818734 0.88 ALOX15 (0.97) LMNAALOX15CYP1A2THRBTSHR
Propyphenazone SCHEMBL23393 0.88 LMNA (1.00) LMNAALOX15CYP1A2ADORA3ALDH1A1
Propyphenazone SCHEMBL7929540 0.87 LMNA (0.97) LMNAALOX15CYP1A2ADORA3ALDH1A1
Aminopyrine SCHEMBL28152267 0.83 ALOX15 (0.85) LMNAALOX15CYP1A2THRBTSHR
Aminopyrine SCHEMBL8723416 0.83 ALOX15 (0.85) LMNAALOX15CYP1A2THRBTSHR
Aminopyrine SCHEMBL10493337 0.81 ALOX15 (0.81) LMNAALOX15CYP1A2THRBTSHR
Aminopyrine SCHEMBL28086243 0.80 ALOX15 (0.78) LMNAALOX15CYP1A2THRBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103717597-B Heterocyclic compounds as kinase inhibitors 原真股份有限公司 2017-07-04 CN disclosed
CN-103492389-B Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases 原真股份有限公司 2016-09-14 CN disclosed