Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.87 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfisomidine SCHEMBL34791 | 0.93 | PDE4A (1.00) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfisomidine SCHEMBL284793 | 0.92 | PDE4A (0.97) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfamethazine SCHEMBL29918086 | 0.89 | ALDH1A1 (1.00) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfamethazine SCHEMBL151305 | 0.89 | ALDH1A1 (1.00) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfamethazine SCHEMBL17256221 | 0.89 | ALDH1A1 (1.00) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfamethazine SCHEMBL28567572 | 0.87 | ALDH1A1 (0.97) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfamethazine SCHEMBL3495558 | 0.87 | ALDH1A1 (0.97) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfamethazine SCHEMBL1442165 | 0.87 | ALDH1A1 (0.97) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfamethazine SCHEMBL28028309 | 0.86 | ALDH1A1 (0.94) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 | |
| Sulfamethazine SCHEMBL11708760 | 0.85 | ALDH1A1 (0.91) | PDE4AAGO2ALDH1A1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |