Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piritramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piritramide SCHEMBL26151 | 0.79 | KCNA3 (0.64) | OPRM1KCNH2ADRA1ALMNAKCNA3 | |
| Propoxyphene SCHEMBL27879801 | 0.77 | OPRM1 (0.82) | OPRM1KCNH2OPRD1ADRA1AMRGPRX2 | |
| Propoxyphene SCHEMBL22578380 | 0.77 | OPRM1 (0.69) | OPRM1KCNH2OPRD1ADRA1AMRGPRX2 | |
| Piritramide SCHEMBL5399631 | 0.76 | KCNA3 (0.57) | OPRM1KCNH2ADRA1ALMNAKCNA3 | |
| Bezitramide SCHEMBL28086670 | 0.76 | OPRM1 (0.52) | OPRM1KCNH2OPRD1ADRA1AMRGPRX2 | |
| Propoxyphene SCHEMBL28792689 | 0.74 | OPRM1 (0.95) | OPRM1KCNH2OPRD1ADRA1AMRGPRX2 | |
| Propoxyphene SCHEMBL23779946 | 0.74 | OPRM1 (1.00) | OPRM1KCNH2OPRD1ADRA1AMRGPRX2 | |
| Levopropoxyphene SCHEMBL158770 | 0.74 | OPRM1 (1.00) | OPRM1KCNH2OPRD1ADRA1AMRGPRX2 | |
| Propoxyphene SCHEMBL8675564 | 0.74 | OPRM1 (1.00) | OPRM1KCNH2OPRD1ADRA1AMRGPRX2 | |
| Propoxyphene SCHEMBL21775586 | 0.74 | OPRM1 (1.00) | OPRM1KCNH2OPRD1ADRA1AMRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |