Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Piritramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.49 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.47 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 8/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piritramide SCHEMBL26151 | 0.94 | KCNA3 (0.64) | KCNA3TSHRCCR1OPRM1CHRM2 | |
| Piritramide SCHEMBL13723412 | 0.80 | KCNA3 (0.44) | KCNA3TSHRCCR1OPRM1CHRM2 | |
| Piritramide SCHEMBL28086563 | 0.76 | OPRM1 (0.55) | KCNA3TSHRCCR1OPRM1CHRM2 | |
| Piritramide SCHEMBL5886171 | 0.75 | OPRM1 (0.67) | KCNA3OPRM1LMNA | |
| SCHEMBL11625051 | 0.75 | KCNA3 (1.00) | KCNA3CCR1OPRM1CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL11628063 | 0.72 | KCNA3 (0.94) | KCNA3CCR1OPRM1CHRM2HTR1A | |
| Difenoxin SCHEMBL123801 | 0.71 | KCNA3 (0.78) | KCNA3CCR1OPRM1RAB9ANPSR1 | |
| SCHEMBL11599516 | 0.71 | KCNA3 (0.84) | KCNA3CCR1OPRM1CHRM2HTR1A | |
| Difenoxin SCHEMBL11604884 | 0.71 | KCNA3 (0.76) | KCNA3CCR1OPRM1RAB9ANPSR1 | |
| Difenoxin SCHEMBL149008 | 0.71 | KCNA3 (0.76) | KCNA3CCR1OPRM1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070166364-A1 | Transdermal Therapeutic System | BEIER CORNELIA | 2007-07-19 | — | — | US | disclosed |
| US-7220473-B2 | Storage stability | HEXAL AG (DE) | 2007-05-22 | — | — | US | disclosed |
| US-20040086552-A1 | Transdermal therapeutic system for highly dispersed silicon dioxide | HEXAL AG (DE) | 2004-05-06 | — | — | US | disclosed |
| US-20040047901-A1 | Storage stability | HEXAL AG (DE) | 2004-03-11 | — | — | US | disclosed |