Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Tetrazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.47 |
| ▸ | GABRA5 known ✓ | P31644 | 4/20 | 0.47 |
| ▸ | GABRA2 known ✓ | P47869 | 4/20 | 0.47 |
| ▸ | GABRG2 known ✓ | P18507 | 3/20 | 0.47 |
| ▸ | GABRB3 known ✓ | P28472 | 3/20 | 0.47 |
| ▸ | GABRA3 known ✓ | P34903 | 3/20 | 0.47 |
| ▸ | GABRB2 known ✓ | P47870 | 3/20 | 0.47 |
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.47 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.47 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.47 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.47 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.47 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.47 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.47 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.47 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrazepam SCHEMBL29500955 | 0.81 | LMNA (0.65) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| Tetrazepam SCHEMBL157998 | 0.81 | LMNA (0.65) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| Tetrazepam SCHEMBL6832326 | 0.80 | LMNA (0.63) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| Fludiazepam SCHEMBL6130061 | 0.76 | GABRA1 (0.57) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| SCHEMBL13352296 | 0.72 | LMNA (0.47) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| Cyclobenzaprine SCHEMBL28142913 | 0.72 | GABRA1 (0.47) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| SCHEMBL5163739 | 0.71 | GABRA1 (0.61) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| Tetrazepam SCHEMBL20586241 | 0.70 | GABRA1 (0.49) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| Diazepam SCHEMBL10489908 | 0.70 | GABRA1 (0.81) | GABRA1GABRA5GABRA2GABRG2GABRB3 | |
| Diazepam SCHEMBL10489949 | 0.69 | GABRA1 (0.88) | GABRA1GABRA5GABRA2GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |