Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.46 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22216392 | 0.86 | MAPK14 (0.60) | MAPK14DRD2DRD3MAPTGPR183 | |
| SCHEMBL31428795 | 0.86 | MAPK14 (0.60) | MAPK14DRD2DRD3MAPTGPR183 | |
| Ethoxycarbonyl Group SCHEMBL28819113 | 0.79 | MAOA (0.51) | MAPT | |
| Ethoxycarbonyl Group SCHEMBL28872615 | 0.78 | AR (0.50) | MAPT | |
| SCHEMBL31428636 | 0.78 | GHSR (0.65) | MAPK14MAPTALDH1A1HSD17B10GHSR | |
| SCHEMBL143751 | 0.78 | GHSR (0.65) | MAPK14MAPTALDH1A1HSD17B10GHSR | |
| Ethoxycarbonyl Group SCHEMBL28014362 | 0.77 | ALDH1A1 (0.51) | MAPK14DRD2DRD3MAPTALDH1A1 | |
| Ethoxycarbonyl Group SCHEMBL28014279 | 0.77 | ALDH1A1 (0.50) | MAPK14MAPTALDH1A1HSD17B10 | |
| Ethoxycarbonyl Group SCHEMBL28014293 | 0.75 | ACHE (0.54) | DRD2DRD3MAPTLMNAL3MBTL1 | |
| SCHEMBL22216445 | 0.75 | MAPK14 (0.64) | MAPK14DRD2DRD3MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105793252-A | Inhibitors of bruton's tyrosine kinase | 豪夫迈·罗氏有限公司 | 2016-07-20 | — | — | CN | disclosed |