Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 3/20 | 0.34 |
| ▸ | PNP | P00491 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.31 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL4460112 | 0.79 | ATAD2 (0.51) | TP53KDM4EGLAALDH1A1LMNA | |
| Guanine SCHEMBL17542295 | 0.79 | ATAD2 (0.36) | KDM4EGLAALDH1A1LMNAPMP22 | |
| Thiouracil SCHEMBL4958659 | 0.79 | TP53 (0.66) | TP53KDM4EMEN1KMT2ATDP1 | |
| Guanine SCHEMBL2499472 | 0.78 | KDM4E (0.50) | TP53KDM4EGLAALDH1A1LMNA | |
| Guanine SCHEMBL4007020 | 0.77 | ATAD2 (0.41) | KDM4EGLAALDH1A1LMNAPMP22 | |
| Guanine SCHEMBL15718980 | 0.75 | KDM4E (0.33) | KDM4EGLAALDH1A1LMNAPMP22 | |
| Guanine SCHEMBL5259 | 0.74 | ALDH1A1 (0.61) | TP53KDM4EGLAALDH1A1LMNA | |
| Guanine SCHEMBL4658042 | 0.74 | ALDH1A1 (0.61) | TP53KDM4EGLAALDH1A1LMNA | |
| Guanine SCHEMBL9468221 | 0.74 | KDM4E (0.32) | KDM4EGLAALDH1A1LMNAPMP22 | |
| Guanine SCHEMBL4301039 | 0.73 | KDM4E (0.44) | KDM4EGLAALDH1A1LMNAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109312339-A | Materials and methods for treating amyotrophic lateral sclerosis and/or frontotemporal lobar degeneration | 克里斯珀医疗股份公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-103608354-B | Nanoparticles containing pH-responsive peptides | 大鹏药品工业株式会社 | 2016-10-05 | — | — | CN | disclosed |