Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL4577873 | 0.92 | ATAD2 (0.43) | ATAD2KDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL4007020 | 0.90 | ATAD2 (0.41) | ATAD2KDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL17542295 | 0.84 | ATAD2 (0.36) | ATAD2KDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL4658042 | 0.84 | ALDH1A1 (0.61) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL5259 | 0.84 | ALDH1A1 (0.61) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL7513533 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL5097008 | 0.84 | ATAD2 (0.36) | ATAD2KDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL9468293 | 0.83 | ATAD2 (0.35) | ATAD2KDM4EALDH1A1LMNAGLA | |
| 2,6-Diaminopurine SCHEMBL1672826 | 0.83 | ATAD2 (0.50) | ATAD2PNPPDPK1PARP1ACHE | |
| Guanine SCHEMBL4301039 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1LMNAGLAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521178-B1 | Method for synthesizing DNA | TAKARA BIO INC. (JP) | 2009-04-21 | — | — | US | claimed |
| US-7034133-B2 | Locked Nucleoside Analogues is a biochemical conjugate of nucleotides; as an aptamer in specific binding of antibiotics, drugs, amino acids, peptides, enzymes, saccharides, polysaccharides; heat resistance | EXIQON A/S (DK) | 2006-04-25 | — | — | US | claimed |
| US-6670461-B1 | Bi-, tri, or polycyclic nucleoside analogues having a \"locked\" structure capable of forming heat resistant nucleobase specific duplexes and triplexes with single and double stranded nucleic acids. | EXIQON A/S (DK) | 2003-12-30 | — | — | US | claimed |
| US-20030208061-A1 | Labeled oligonucleotides, methods for making same, and compounds useful therefor | ISIS PHARMACEUTICALS, INC. | 2003-11-06 | — | — | US | claimed |
| CN-115491418-A | Second-generation sequencing panel of target genes with congenital incomplete lens dislocation and sequencing method | 复旦大学附属眼耳鼻喉科医院 | 2022-12-20 | — | — | CN | disclosed |
| US-11279736-B2 | Conformationally-preorganized, MiniPEG-containing gamma-peptide nucleic acids | CARNEGIE MELLON UNIVERSITY (US) | 2022-03-22 | — | — | US | disclosed |
| US-20210214397-A1 | CONFORMATIONALLY-PREORGANIZED, MiniPEG-CONTAINING GAMMA-PEPTIDE NUCLEIC ACIDS | CARNEGIE MELLON UNIVERSITY (US) | 2021-07-15 | — | — | US | disclosed |
| CN-111867626-A | Methods and compositions for treating amyloid deposition diseases | 纽约哥伦比亚大学理事会 | 2020-10-30 | — | — | CN | disclosed |
| US-20060141511-A1 | Chemical amplification for the synthesis of patterned arrays | AFFYMETRIX, INC (US) | 2006-06-29 | — | — | US | disclosed |
| US-20050181421-A1 | Methods of array synthesis | AFFYMETRIX, INC. (US) | 2005-08-18 | — | — | US | disclosed |
| EP-1559785-A1 | Oligo- or polynucleotides for achieving RNA interference in mammalian cells | Bio-Think Tank Co., Ltd. (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6770436-B1 | RADIATION-ACTIVATED CATALYSTS (RACS), AUTOCATALYTIC REACTIONS, AND PROTECTIVE GROUPS ARE EMPLOYED TO ACHIEVE A HIGHLY SENSITIVE, HIGH RESOLUTION, RADIATION DIRECTED COMBINATORIAL SYNTHESIS OF PATTERN ARRAYS OF DIVERSE POLYMERS | AFFYMETRIX, INC. | 2004-08-03 | — | — | US | disclosed |
| US-20020122874-A1 | Process for preparing peptide nucleic acid probe using polymeric photoacid generator | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2002-09-05 | — | — | US | disclosed |
| WO-1997001634-A3 | POLYPEPTIDE FOR REPAIRING GENETIC INFORMATION, NUCLEOTIDIC SEQUENCE WHICH CODES FOR IT AND PROCESS FOR THE PREPARATION THEREOF (GUANINE THYMINE BINDING PROTEIN - GTBP) | ANGELETTI P IST RICHERCHE BIO (IT) | 1997-04-03 | — | — | WO | disclosed |
| WO-1997001634-A3 | POLYPEPTIDE FOR REPAIRING GENETIC INFORMATION, NUCLEOTIDIC SEQUENCE WHICH CODES FOR IT AND PROCESS FOR THE PREPARATION THEREOF (GUANINE THYMINE BINDING PROTEIN - GTBP) | ANGELETTI P IST RICHERCHE BIO (IT) | 1997-04-03 | — | — | WO | disclosed |
| WO-1997001634-A2 | POLYPEPTIDE FOR REPAIRING GENETIC INFORMATION, NUCLEOTIDIC SEQUENCE WHICH CODES FOR IT AND PROCESS FOR THE PREPARATION THEREOF (GUANINE THYMINE BINDING PROTEIN - GTBP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 1997-01-16 | — | — | WO | disclosed |
| WO-1997001634-A2 | POLYPEPTIDE FOR REPAIRING GENETIC INFORMATION, NUCLEOTIDIC SEQUENCE WHICH CODES FOR IT AND PROCESS FOR THE PREPARATION THEREOF (GUANINE THYMINE BINDING PROTEIN - GTBP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 1997-01-16 | — | — | WO | disclosed |
| WO-1997001634-A2 | POLYPEPTIDE FOR REPAIRING GENETIC INFORMATION, NUCLEOTIDIC SEQUENCE WHICH CODES FOR IT AND PROCESS FOR THE PREPARATION THEREOF (GUANINE THYMINE BINDING PROTEIN - GTBP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 1997-01-16 | — | — | WO | disclosed |
| EP-0639200-A1 | METHODS AND REAGENTS FOR CLEAVING AND DEPROTECTING OLIGONUCLEOTIDES | BECKMAN INSTRUMENTS, INC. (US) | 1995-02-22 | — | — | EP | disclosed |
| WO-1993022329-A1 | METHODS AND REAGENTS FOR CLEAVING AND DEPROTECTING OLIGONUCLEOTIDES | BECKMAN INSTRUMENTS, INC. (US) | 1993-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030208061-A1 | Labeled oligonucleotides, methods for making same, and compounds useful therefor | METTL16, BCDIN3D, GARS1 | ATAD2 4679/4885KDM4E 2851/4885ALDH1A1 1042/4885 |
| US-20050181421-A1 | Methods of array synthesis | RAC2, RAC3, RAC1 | ATAD2 2880/4885KDM4E 4170/4885ALDH1A1 2290/4885 |
| US-11279736-B2 | Conformationally-preorganized, MiniPEG-containing gamma-peptide nucleic acids | POLL, PCNA, POLG | ATAD2 2136/4885KDM4E 4658/4885ALDH1A1 4116/4885 |
| US-20060141511-A1 | Chemical amplification for the synthesis of patterned arrays | PARG, RAD18, RAC2 | ATAD2 2213/4885KDM4E 4005/4885ALDH1A1 1710/4885 |
| US-20210214397-A1 | CONFORMATIONALLY-PREORGANIZED, MiniPEG-CONTAINING GAMMA-PEPTIDE NUCLEIC ACIDS | POLL, PCNA, POLG | ATAD2 2136/4885KDM4E 4658/4885ALDH1A1 4116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.