Thiophene

Thiophene

SCHEMBL28091067

Cc1cc2ccccn2c1.c1ccsc1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.40
ALDH1A1 P00352 2/20 0.40
POLB P06746 2/20 0.40
MAPT P10636 2/20 0.40
RAB9A P51151 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ALOX15 P16050 1/20 0.39
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
SSTR4 P31391 1/20 0.32
HRH3 Q9Y5N1 1/20 0.31
CHRNA7 P36544 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL321553 0.89 ALOX15 (0.48) NPC1ALDH1A1POLBMAPTRAB9A
1,2-Dichloroethane SCHEMBL27922038 0.80 NPC1 (0.41) NPC1ALDH1A1POLBMAPTRAB9A
Thiophene SCHEMBL4266475 0.74 ALOX15 (0.71) NPC1ALDH1A1POLBMAPTRAB9A
SCHEMBL873426 0.69 ALDH1A1 (0.62) NPC1ALDH1A1POLBMAPTRAB9A
SCHEMBL149606 0.68 NPC1 (0.51) NPC1ALDH1A1POLBMAPTRAB9A
SCHEMBL22515602 0.67 ALOX15 (0.46) NPC1ALDH1A1POLBMAPTRAB9A
Toluene SCHEMBL28181662 0.67 ACHE (0.61) NPC1ALDH1A1POLBRAB9ASMN1; SMN2
SCHEMBL3884828 0.67 SMN1; SMN2 (0.58) NPC1ALDH1A1POLBMAPTRAB9A
SCHEMBL7173450 0.67 NPC1 (0.54) NPC1ALDH1A1POLBMAPTRAB9A
SCHEMBL4566858 0.66 ALOX15 (0.50) NPC1ALDH1A1POLBMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105874633-A High voltage organic materials for energy storage applications 丰田自动车欧洲股份有限公司 2016-08-17 CN disclosed