Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.35 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28084468 | 0.82 | KDR (0.46) | HPGDEPHX2 | |
| SCHEMBL4015709 | 0.75 | HDAC1 (0.49) | KMT2AGRIK1HDAC1HDAC8HDAC6 | |
| SCHEMBL31642971 | 0.72 | KMT2A (0.48) | KMT2AMAPTGSK3AGSK3BAAK1 | |
| SCHEMBL27344331 | 0.71 | AAK1 (0.42) | KMT2AHPGDHTTAAK1SMN1; SMN2 | |
| SCHEMBL28263497 | 0.71 | GAA (0.53) | L3MBTL1KMT2AHPGDHTTMAPT | |
| SCHEMBL16096500 | 0.71 | TGM2 (0.50) | GRIK1HDAC1HDAC8HDAC6HTT | |
| SCHEMBL28093557 | 0.69 | GRIK1 (0.42) | KMT2AGRIK1HDAC1HDAC8HDAC6 | |
| SCHEMBL5554181 | 0.68 | MAPT (0.57) | KMT2AHTTMAPTGAASMN1; SMN2 | |
| SCHEMBL28263496 | 0.67 | RAB9A (0.53) | L3MBTL1KMT2AHTTGAASMN1; SMN2 | |
| SCHEMBL28084454 | 0.67 | KDR (0.48) | KMT2AABL1GAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906568-A | Cyclopropane diamide compound with antitumor activity and preparation method and application thereof | 西安交通大学 | 2016-08-31 | — | — | CN | disclosed |