Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.42 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | XPO1 | O14980 | 1/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16096500 | 0.81 | TGM2 (0.50) | HDAC1HDAC8HDAC6GRIK1SMN1; SMN2 | |
| SCHEMBL28093557 | 0.79 | GRIK1 (0.42) | HDAC1HDAC8HDAC6GRIK1SMN1; SMN2 | |
| SCHEMBL20357210 | 0.79 | HTT (0.62) | HDAC1HDAC8HDAC6GRIK1SMN1; SMN2 | |
| SCHEMBL14053110 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL17498094 | 0.77 | NPC1 (0.49) | HDAC1HDAC8HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL1726652 | 0.76 | HDAC1 (0.43) | HDAC1HDAC8HDAC6GRIK1ALDH1A1 | |
| SCHEMBL1727024 | 0.76 | TRPV4 (0.44) | HDAC1HDAC8HDAC6ALDH1A1TSHR | |
| SCHEMBL28093556 | 0.75 | L3MBTL1 (0.39) | HDAC1HDAC8HDAC6GRIK1SMN1; SMN2 | |
| SCHEMBL1008398 | 0.74 | POLB (0.63) | GRIK1SMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL22749629 | 0.74 | ALDH1A1 (0.51) | HDAC1HDAC8HDAC6SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2009-10-29 | — | — | US | disclosed |
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270418-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | MAP3K1, MAP3K15, MAP3K5 | HDAC1 403/4885HDAC8 890/4885HDAC6 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.